Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

DNA replicates once per cell cycle. Interfering with the regulation of DNA replication initiation generates genome instability through over-replication and has been linked to early stages of cancer development. Here, we engineer genetic systems in budding yeast to induce unscheduled replication in a...

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Detalles Bibliográficos
Autores principales: Reusswig, Karl-Uwe, Bittmann, Julia, Peritore, Martina, Courtes, Mathilde, Pardo, Benjamin, Wierer, Michael, Mann, Matthias, Pfander, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674678/
https://www.ncbi.nlm.nih.gov/pubmed/36400763
http://dx.doi.org/10.1038/s41467-022-34379-2

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