In silico design of EGFR(L858R/T790M/C797S) inhibitors via 3D-QSAR, molecular docking, ADMET properties and molecular dynamics simulations

The development of L858R/T790M/C797S mutations in EGFR is one of the main reasons for the emergence of resistance after third-generation treatment of non-small cell lung cancer (NSCLC). Therefore, the development of 4th generation drugs needs urgent attention. To overcome resistance, in silico drug...

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Detalles Bibliográficos
Autores principales: Hadni, Hanine, Elhallaouia, Menana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674911/
https://www.ncbi.nlm.nih.gov/pubmed/36411890
http://dx.doi.org/10.1016/j.heliyon.2022.e11537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674911/
https://www.ncbi.nlm.nih.gov/pubmed/36411890
http://dx.doi.org/10.1016/j.heliyon.2022.e11537

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