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Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury
Lipoprotein modification by reactive dicarbonyls, including isolevuglandin (IsoLG), produces dysfunctional particles. Kidneys participate in lipoprotein metabolism, including tubular uptake. However, the process beyond the proximal tubule is unclear, as is the effect of kidney injury on this pathway...
Autores principales: | Zhong, Jianyong, Yang, Hai-Chun, Shelton, Elaine L., Matsusaka, Taiji, Clark, Amanda J., Yermalitsky, Valery, Mashhadi, Zahra, May-Zhang, Linda S., Linton, MacRae F., Fogo, Agnes B., Kirabo, Annet, Davies, Sean S., Kon, Valentina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675465/ https://www.ncbi.nlm.nih.gov/pubmed/36125905 http://dx.doi.org/10.1172/jci.insight.161878 |
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