A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice

Primary immune regulatory disorders (PIRD) represent a group of disorders characterized by immune dysregulation, presenting with a wide range of clinical disease, including autoimmunity, autoinflammation, or lymphoproliferation. Autosomal dominant germline gain-of-function (GOF) variants in STAT3 re...

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Detalles Bibliográficos
Autores principales: Schmitt, Erica G., Toth, Kelsey A., Risma, Samuel I., Kolicheski, Ana, Saucier, Nermina, Berríos, Rafael J. Feliciano, Greenberg, Zev J., Leiding, Jennifer W., Bleesing, Jack J., Thatayatikom, Akaluck, Schuettpelz, Laura G., Edwards, John R., Vogel, Tiphanie P., Cooper, Megan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675480/
https://www.ncbi.nlm.nih.gov/pubmed/36136607
http://dx.doi.org/10.1172/jci.insight.162695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675480/
https://www.ncbi.nlm.nih.gov/pubmed/36136607
http://dx.doi.org/10.1172/jci.insight.162695

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