Cargando…

A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice

Primary immune regulatory disorders (PIRD) represent a group of disorders characterized by immune dysregulation, presenting with a wide range of clinical disease, including autoimmunity, autoinflammation, or lymphoproliferation. Autosomal dominant germline gain-of-function (GOF) variants in STAT3 re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmitt, Erica G., Toth, Kelsey A., Risma, Samuel I., Kolicheski, Ana, Saucier, Nermina, Berríos, Rafael J. Feliciano, Greenberg, Zev J., Leiding, Jennifer W., Bleesing, Jack J., Thatayatikom, Akaluck, Schuettpelz, Laura G., Edwards, John R., Vogel, Tiphanie P., Cooper, Megan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675480/ https://www.ncbi.nlm.nih.gov/pubmed/36136607 http://dx.doi.org/10.1172/jci.insight.162695

Ejemplares similares

Long-term efficacy of sialendoscopy in treating childhood Sjögren’s disease with chronological monitoring by salivary gland ultrasonography: A novel approach
por: Drew, Kristin, et al.
Publicado: (2023)

STAT3 gain-of-function syndrome
por: Vogel, Tiphanie P., et al.
Publicado: (2023)

The Diagnostic Performance of Early Sjögren’s Syndrome Autoantibodies in Juvenile Sjögren’s Syndrome: The University of Florida Pediatric Cohort Study
por: Thatayatikom, Akaluck, et al.
Publicado: (2021)

NADPH oxidase 2 limits amplification of IL-1β–G-CSF axis and an immature neutrophil subset in murine lung inflammation
por: Song, Zhimin, et al.
Publicado: (2022)

Toll-like receptor and cytokine expression throughout the bone marrow differs between patients with low- and high-risk myelodysplastic syndromes
por: Paracatu, Luana Chiquetto, et al.
Publicado: (2022)

Editorial: Dysregulation of Th17 and Treg cells in autoimmune diseases
por: Astier, Anne L., et al.
Publicado: (2023)

The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome
por: Ganesh, Ravindra, et al.
Publicado: (2022)

Gain-of-function defects in toll-like receptor 8 shed light on the interface between immune system and bone marrow failure disorders
por: Bleesing, Jack
Publicado: (2022)

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis
por: Mellor-Heineke, Sabine, et al.
Publicado: (2013)

Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells
por: Edwards, Emily S. J., et al.
Publicado: (2019)

TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS
por: Monlish, Darlene A., et al.
Publicado: (2020)

The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex–mediated quiescence
por: Greenberg, Zev J., et al.
Publicado: (2023)

Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-predominant Irritable Bowel Syndrome
por: Aggarwal, Surbhi, et al.
Publicado: (2018)

Attachment, Emotion Dysregulation, and Physical IPV in Predominantly Hispanic, Young Adult Couples
por: Pollard, Deanna L., et al.
Publicado: (2021)

Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation
por: Burnett, Deborah L, et al.
Publicado: (2017)

Dysregulated immunity in PID patients with low GARP expression on Tregs due to mutations in LRRC32
por: Lehmkuhl, Peter, et al.
Publicado: (2021)

The correlation between Th17/Treg immune dysregulation and the disease severity in chronic spontaneous urticaria patients
por: Yang, Xiaojing, et al.
Publicado: (2023)

Juvenile Sjögren's Syndrome: Clinical Characteristics With Focus on Salivary Gland Ultrasonography
por: Hammenfors, Daniel S., et al.
Publicado: (2019)

Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients
por: Gutiérrez, Carolina, et al.
Publicado: (2019)

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127(pos) Depletion, Treg Expansion, and Treg Cryopreservation
por: Peters, Jorieke H., et al.
Publicado: (2008)

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs
por: Wienke, Judith, et al.
Publicado: (2020)

Immune dysregulation in patients with TRNT1 deficiency
por: Giannelou, A, et al.
Publicado: (2015)

Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis
por: Hilliard, Kinsey A., et al.
Publicado: (2022)

The role of Treg subtypes in glomerulonephritis
por: Herrnstadt, G. R., et al.
Publicado: (2020)

The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes
por: Higgins, Cassandra B., et al.
Publicado: (2022)

Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression
por: Donnelly, Conor, et al.
Publicado: (2018)

Treg/IL-17 Ratio and Treg Differentiation in Patients with COPD
por: Jin, Yang, et al.
Publicado: (2014)

Pathological conditions re-shape physiological Tregs into pathological Tregs
por: Yang, William Y, et al.
Publicado: (2015)

ICOS(+) Tregs: A Functional Subset of Tregs in Immune Diseases
por: Li, Dan-Yang, et al.
Publicado: (2020)

Alterations in function and distribution of regulatory T Cells (Tregs) may blunt vaccine induced immune responses in HIV infection
por: van Lunzen, J, et al.
Publicado: (2012)

TNFR2: The new Treg switch?
por: Cohen, José L., et al.
Publicado: (2017)

Corrigendum: ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
por: Li, Dan-Yang, et al.
Publicado: (2021)

VIP Regulates the Development & Proliferation of Treg in vivo in spleen
por: Szema, Anthony M, et al.
Publicado: (2011)

TLR-2 expression and dysregulated human Treg/Th17 phenotype in Aspergillus flavus infected patients of chronic rhinosinusitis with nasal polyposis
por: Rai, Gargi, et al.
Publicado: (2020)

Predominant risk factors for tick-borne co-infections in hunting dogs from the USA
por: Mahachi, Kurayi, et al.
Publicado: (2020)

Regulation of Hematopoietic Stem Cell Activity by Inflammation
por: Schuettpelz, Laura G., et al.
Publicado: (2013)

Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes
por: Paracatu, Luana Chiquetto, et al.
Publicado: (2020)

Prognostic values of regulatory T cells (Tregs) and Treg-related genes in gastric cancer
por: Zheng, Liang, et al.
Publicado: (2023)

From Colon to Aortic Aneurysm: Trek of the Treg
por: Freedman, Neil J.
Publicado: (2022)

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg
por: Xu, Keman, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a53r8767thg731ll956e0un6ks