Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment

To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis 1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas, benign tumors driven by NF1 loss in Schwann cells (SCs). By comparing normal nerve cells to plexiform neurofibroma (PN) c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kershner, Leah J., Choi, Kwangmin, Wu, Jianqiang, Zhang, Xiyuan, Perrino, Melissa, Salomonis, Nathan, Shern, Jack F., Ratner, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675562/
https://www.ncbi.nlm.nih.gov/pubmed/36134665
http://dx.doi.org/10.1172/jci.insight.154513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675562/
https://www.ncbi.nlm.nih.gov/pubmed/36134665
http://dx.doi.org/10.1172/jci.insight.154513

Ejemplares similares