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Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy

IgA nephropathy (IgAN) is an autoimmune disease characterized by the deposition of galactose-deficient IgA1 (Gd-IgA1)-containing immune complexes in the kidneys. Elevated serum levels of Gd-IgA1, the main autoantigen in IgAN, are associated with mucosal infections and poor renal outcome in IgAN pati...

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Detalles Bibliográficos
Autores principales: Reily, Colin, Rice, Terri, Crossman, David K., Rizk, Dana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675727/
https://www.ncbi.nlm.nih.gov/pubmed/35987175
http://dx.doi.org/10.1016/j.jaut.2022.102883