BRAF activation by metabolic stress promotes glycolysis sensitizing NRAS(Q61)-mutated melanomas to targeted therapy

NRAS-mutated melanoma lacks a specific line of treatment. Metabolic reprogramming is considered a novel target to control cancer; however, NRAS-oncogene contribution to this cancer hallmark is mostly unknown. Here, we show that NRAS(Q61)-mutated melanomas specific metabolic settings mediate cell sen...

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Detalles Bibliográficos
Autores principales: McGrail, Kimberley, Granado-Martínez, Paula, Esteve-Puig, Rosaura, García-Ortega, Sara, Ding, Yuxin, Sánchez-Redondo, Sara, Ferrer, Berta, Hernandez-Losa, Javier, Canals, Francesc, Manzano, Anna, Navarro-Sabaté, Aura, Bartrons, Ramón, Yanes, Oscar, Pérez-Alea, Mileidys, Muñoz-Couselo, Eva, Garcia-Patos, Vicenç, Recio, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675737/
https://www.ncbi.nlm.nih.gov/pubmed/36402789
http://dx.doi.org/10.1038/s41467-022-34907-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675737/
https://www.ncbi.nlm.nih.gov/pubmed/36402789
http://dx.doi.org/10.1038/s41467-022-34907-0

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