Searching glycolate oxidase inhibitors based on QSAR, molecular docking, and molecular dynamic simulation approaches

Primary hyperoxaluria type 1 (PHT1) treatment is mainly focused on inhibiting the enzyme glycolate oxidase, which plays a pivotal role in the production of glyoxylate, which undergoes oxidation to produce oxalate. When the renal secretion capacity exceeds, calcium oxalate forms stones that accumulat...

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Detalles Bibliográficos
Autores principales: Cabrera, Nicolás, Cuesta, Sebastián A., Mora, José R., Paz, José Luis, Márquez, Edgar A., Espinoza-Montero, Patricio J., Marrero-Ponce, Yovani, Pérez, Noel, Contreras-Torres, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675741/
https://www.ncbi.nlm.nih.gov/pubmed/36402831
http://dx.doi.org/10.1038/s41598-022-24196-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675741/
https://www.ncbi.nlm.nih.gov/pubmed/36402831
http://dx.doi.org/10.1038/s41598-022-24196-4

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