Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

The absence of dystrophin in Duchenne muscular dystrophy disrupts the dystrophin-associated glycoprotein complex resulting in skeletal muscle fiber fragility and atrophy, associated with fibrosis as well as microtubule and neuromuscular junction disorganization. The specific, non-conventional cytopl...

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Detalles Bibliográficos
Autores principales: Osseni, Alexis, Ravel-Chapuis, Aymeric, Belotti, Edwige, Scionti, Isabella, Gangloff, Yann-Gaël, Moncollin, Vincent, Mazelin, Laetitia, Mounier, Remi, Leblanc, Pascal, Jasmin, Bernard J., Schaeffer, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675748/
https://www.ncbi.nlm.nih.gov/pubmed/36402791
http://dx.doi.org/10.1038/s41467-022-34831-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675748/
https://www.ncbi.nlm.nih.gov/pubmed/36402791
http://dx.doi.org/10.1038/s41467-022-34831-3

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