Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state

APOBEC3 proteins (A3s) are enzymes that catalyze the deamination of cytidine to uridine in single-stranded DNA (ssDNA) substrates, thus playing a key role in innate antiviral immunity. However, the APOBEC3 family has also been linked to many mutational signatures in cancer cells, which has led to an...

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Detalles Bibliográficos
Autores principales: Maiti, Atanu, Hedger, Adam K., Myint, Wazo, Balachandran, Vanivilasini, Watts, Jonathan K., Schiffer, Celia A., Matsuo, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675756/
https://www.ncbi.nlm.nih.gov/pubmed/36402773
http://dx.doi.org/10.1038/s41467-022-34752-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675756/
https://www.ncbi.nlm.nih.gov/pubmed/36402773
http://dx.doi.org/10.1038/s41467-022-34752-1

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