The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells

DNA polymerase epsilon (PolE) in an enzyme essential for DNA replication. Deficiencies and mutations in PolE cause severe developmental abnormalities and cancers. Paradoxically, the catalytic domain of yeast PolE catalytic subunit is dispensable for survival, and its non-catalytic essential function...

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Detalles Bibliográficos
Autores principales: Vipat, Sameera, Gupta, Dipika, Jonchhe, Sagun, Anderspuk, Hele, Rothenberg, Eli, Moiseeva, Tatiana N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675812/
https://www.ncbi.nlm.nih.gov/pubmed/36402816
http://dx.doi.org/10.1038/s41467-022-34911-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675812/
https://www.ncbi.nlm.nih.gov/pubmed/36402816
http://dx.doi.org/10.1038/s41467-022-34911-4

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