DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance

DNA is well-documented to stimulate immune response. However, the nature of the DNA to activate immune surveillance is less understood. Here, we show that the activation of cyclic GMP-AMP synthase (cGAS) depends on DNA mechanical flexibility, which is controlled by DNA-sequence, -damage and -length....

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Detalles Bibliográficos
Autores principales: Wang, Lina, Li, Siru, Wang, Kai, Wang, Na, Liu, Qiaoling, Sun, Zhen, Wang, Li, Wang, Lulu, Liu, Quentin, Song, Chengli, Liu, Caigang, Yang, Qingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675814/
https://www.ncbi.nlm.nih.gov/pubmed/36402783
http://dx.doi.org/10.1038/s41467-022-34858-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675814/
https://www.ncbi.nlm.nih.gov/pubmed/36402783
http://dx.doi.org/10.1038/s41467-022-34858-6

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