HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve

HIF1A is significantly upregulated in calcified human aortic valves (AVs). Furthermore, HIF1A inhibitor PX-478 was shown to inhibit AV calcification under static and disturbed flow conditions. Since elevated stretch is one of the major mechanical stimuli for AV calcification, we investigated the eff...

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Detalles Bibliográficos
Autores principales: Salim, Md Tausif, Villa-Roel, Nicolas, Vogel, Booth, Jo, Hanjoong, Yoganathan, Ajit P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676244/
https://www.ncbi.nlm.nih.gov/pubmed/36419483
http://dx.doi.org/10.3389/fcvm.2022.1002067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676244/
https://www.ncbi.nlm.nih.gov/pubmed/36419483
http://dx.doi.org/10.3389/fcvm.2022.1002067

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