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HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve
HIF1A is significantly upregulated in calcified human aortic valves (AVs). Furthermore, HIF1A inhibitor PX-478 was shown to inhibit AV calcification under static and disturbed flow conditions. Since elevated stretch is one of the major mechanical stimuli for AV calcification, we investigated the eff...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676244/ https://www.ncbi.nlm.nih.gov/pubmed/36419483 http://dx.doi.org/10.3389/fcvm.2022.1002067 |