PROTACs in gastrointestinal cancers

Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase ligand covalently linked to a protein of interest (POI) via a linker. PROTAC can induce ubiquitinated proteasomal degradation of...

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Detalles Bibliográficos
Autores principales: Chen, Yu, Yang, Qingfan, Xu, Jinrun, Tang, Liyao, Zhang, Yan, Du, Fukuan, Zhao, Yueshui, Wu, Xu, Li, Mingxing, Shen, Jing, Ding, Ruilin, Cao, Hongying, Li, Wanping, Li, Xiaobing, Chen, Meijuan, Wu, Zhigui, Cho, Chi Hin, Du, Yu, Wen, Qinglian, Xiao, Zhangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676279/
https://www.ncbi.nlm.nih.gov/pubmed/36420306
http://dx.doi.org/10.1016/j.omto.2022.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676279/
https://www.ncbi.nlm.nih.gov/pubmed/36420306
http://dx.doi.org/10.1016/j.omto.2022.10.012

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