Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

OBJECTIVES: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted inhibition of FOXO1. We have previously shown that th...

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Detalles Bibliográficos
Autores principales: Lee, Yun-Kyoung, Du, Wen, Nie, Yaohui, Diaz, Bryan, Sultana, Nishat, Kitamoto, Takumi, Leibel, Rudolph L., Accili, Domenico, Belvedere, Sandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676376/
https://www.ncbi.nlm.nih.gov/pubmed/36283677
http://dx.doi.org/10.1016/j.molmet.2022.101618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676376/
https://www.ncbi.nlm.nih.gov/pubmed/36283677
http://dx.doi.org/10.1016/j.molmet.2022.101618

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