Binding pocket stabilization by high-throughput screening of yeast display libraries

Protein dynamics have a great influence on the binding pockets of some therapeutic targets. Flexible protein binding sites can result in transient binding pocket formation which might have a negative impact on drug screening efforts. Here, we describe a protein engineering strategy with FK506-bindin...

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Detalles Bibliográficos
Autores principales: Lerma Romero, Jorge A., Meyners, Christian, Christmann, Andreas, Reinbold, Lisa M., Charalampidou, Anna, Hausch, Felix, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676650/
https://www.ncbi.nlm.nih.gov/pubmed/36419931
http://dx.doi.org/10.3389/fmolb.2022.1023131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676650/
https://www.ncbi.nlm.nih.gov/pubmed/36419931
http://dx.doi.org/10.3389/fmolb.2022.1023131

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