Repurposing the lineage-determining transcription factor Atoh1 without redistributing its genomic binding sites

Although the lineage-determining ability of transcription factors is often modulated according to cellular context, the mechanisms by which such switching occurs are not well known. Using a transcriptional programming model, we found that Atoh1 is repurposed from a neuronal to an inner ear hair cell...

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Detalles Bibliográficos
Autores principales: Costa, Aida, Powell, Lynn M., Malaguti, Mattias, Soufi, Abdenour, Lowell, Sally, Jarman, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676683/
https://www.ncbi.nlm.nih.gov/pubmed/36420143
http://dx.doi.org/10.3389/fcell.2022.1016367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676683/
https://www.ncbi.nlm.nih.gov/pubmed/36420143
http://dx.doi.org/10.3389/fcell.2022.1016367

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