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Repurposing the lineage-determining transcription factor Atoh1 without redistributing its genomic binding sites
Although the lineage-determining ability of transcription factors is often modulated according to cellular context, the mechanisms by which such switching occurs are not well known. Using a transcriptional programming model, we found that Atoh1 is repurposed from a neuronal to an inner ear hair cell...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676683/ https://www.ncbi.nlm.nih.gov/pubmed/36420143 http://dx.doi.org/10.3389/fcell.2022.1016367 |