p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models

The activation of the p53 pathway has been associated with neuronal degeneration in different neurological disorders, including spinal muscular atrophy (SMA) where aberrant expression of p53 drives selective death of motor neurons destined to degenerate. Since direct p53 inhibition is an unsound the...

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Detalles Bibliográficos
Autores principales: Buettner, Jannik M., Sowoidnich, Leonie, Gerstner, Florian, Blanco-Redondo, Beatriz, Hallermann, Stefan, Simon, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676941/
https://www.ncbi.nlm.nih.gov/pubmed/36419936
http://dx.doi.org/10.3389/fncel.2022.1038276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676941/
https://www.ncbi.nlm.nih.gov/pubmed/36419936
http://dx.doi.org/10.3389/fncel.2022.1038276

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