Cargando…

Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice

The type 2 Ca(2+)-dependent activator protein for secretion (CAPS2/CADPS2) regulates dense-core vesicle trafficking and exocytosis and is involved in the regulated release of catecholamines, peptidergic hormones, and neuromodulators. CAPS2 is expressed in the pancreatic exocrine acinar cells that pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sato, Yotaroh, Tsuyusaki, Miho, Takahashi-Iwanaga, Hiromi, Fujisawa, Rena, Masamune, Atsushi, Hamada, Shin, Matsumoto, Ryotaro, Tanaka, Yu, Kakuta, Yoichi, Yamaguchi-Kabata, Yumi, Furuse, Tamio, Wakana, Shigeharu, Shimura, Takuya, Kobayashi, Rika, Shinoda, Yo, Goitsuka, Ryo, Maezawa, So, Sadakata, Tetsushi, Sano, Yoshitake, Furuichi, Teiichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676974/ https://www.ncbi.nlm.nih.gov/pubmed/36419930 http://dx.doi.org/10.3389/fmolb.2022.1040237

Ejemplares similares

Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2/Cadps2 Copy Number and Alternative Splicing Variants
por: Sadakata, Tetsushi, et al.
Publicado: (2013)

Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice
por: Mishima, Yuriko, et al.
Publicado: (2015)

Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments
por: Yoshikawa, Fumio, et al.
Publicado: (2016)

CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus
por: Shinoda, Yo, et al.
Publicado: (2016)

Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants
por: Sadakata, Tetsushi, et al.
Publicado: (2007)

The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells
por: Furuichi, Teiichi, et al.
Publicado: (2021)

CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning
por: Ishii, Chiaki, et al.
Publicado: (2021)

The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination
por: Hayashi, Kanehiro, et al.
Publicado: (2017)

The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice
por: Sugimoto, Hisako, et al.
Publicado: (2021)

Combining SLiVER with CADP to Analyze Multi-agent Systems
por: Di Stefano, Luca, et al.
Publicado: (2020)

Oxytocinergic projection from the hypothalamus to supramammillary nucleus drives recognition memory in mice
por: Takahashi, Junpei, et al.
Publicado: (2023)

Axonal Localization of Ca(2+)-Dependent Activator Protein for Secretion 2 Is Critical for Subcellular Locality of Brain-Derived Neurotrophic Factor and Neurotrophin-3 Release Affecting Proper Development of Postnatal Mouse Cerebellum
por: Sadakata, Tetsushi, et al.
Publicado: (2014)

ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response
por: Umemori, Juzoh, et al.
Publicado: (2013)

Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders
por: Yoshizaki, Kaichi, et al.
Publicado: (2016)

Rubber tail illusion is weakened in Ca(2+)-dependent activator protein for secretion 2 (Caps2)-knockout mice
por: Wada, Makoto, et al.
Publicado: (2019)

Task-Related c-Fos Expression in the Posterior Parietal Cortex During the “Rubber Tail Task” Is Diminished in Ca(2+)-Dependent Activator Protein for Secretion 2 (Caps2)-Knockout Mice
por: Wada, Makoto, et al.
Publicado: (2021)

Phospholipase D Family Member 4, a Transmembrane Glycoprotein with No Phospholipase D Activity, Expression in Spleen and Early Postnatal Microglia
por: Yoshikawa, Fumio, et al.
Publicado: (2010)

Homozygous CADPS2 Mutations Cause Neurodegenerative Disease with Lewy Body‐like Pathology in Parrots
por: Lorenzo‐Betancor, Oswaldo, et al.
Publicado: (2022)

Maternally inherited genetic variants of CADPS2 are present in Autism Spectrum Disorders and Intellectual Disability patients
por: Bonora, Elena, et al.
Publicado: (2014)

Maternally inherited genetic variants of CADPS2 are present in Autism Spectrum Disorders and Intellectual Disability patients
por: Bonora, Elena, et al.
Publicado: (2014)

A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
por: Furuse, Tamio, et al.
Publicado: (2019)

Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians
por: Irie, Masahito, et al.
Publicado: (2015)

A novel ENU-induced Cpox mutation causes microcytic hypochromic anemia in mice
por: Miyasaka, Yuki, et al.
Publicado: (2022)

Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny
por: Furuse, Tamio, et al.
Publicado: (2017)

Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions
por: Shimazu, Tadahiro, et al.
Publicado: (2018)

Comprehensive Profiling of Gene Expression in the Cerebral Cortex and Striatum of BTBRTF/ArtRbrc Mice Compared to C57BL/6J Mice
por: Mizuno, Shota, et al.
Publicado: (2020)

A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors
por: Zheng, Guo-Wan, et al.
Publicado: (2020)

Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour
por: Uemura, Masato, et al.
Publicado: (2022)

Cortico-amygdala interaction determines the insular cortical neurons involved in taste memory retrieval
por: Abe, Konami, et al.
Publicado: (2020)

Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition
por: Naruse, Mie, et al.
Publicado: (2014)

LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing
por: Koebis, Michinori, et al.
Publicado: (2019)

The Homer family proteins
por: Shiraishi-Yamaguchi, Yoko, et al.
Publicado: (2007)

Cystic Neoplasms of the Exocrine Pancreas
por: Mosimann, F., et al.
Publicado: (1990)

Diabetes mellitus and the exocrine pancreas.
por: Gorelick, F. S.
Publicado: (1983)

Deletion Involving the 7q31-32 Band at the CADPS2 Gene Locus in a Patient with Autism Spectrum Disorder and Recurrent Psychotic Syndrome Triggered by Stress
por: Grabowski, Paulo André Pera, et al.
Publicado: (2017)

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene
por: Hirose, Michiko, et al.
Publicado: (2017)

Endoscopic radial incision and cutting for Crohn’s Disease-associated intestinal stricture: a pilot study
por: Moroi, Rintaro, et al.
Publicado: (2020)

Excitation of prefrontal cortical neurons during conditioning enhances fear memory formation
por: Shibano, Natsumi, et al.
Publicado: (2020)

Very-KIND, a KIND domain–containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2
por: Huang, Jinhong, et al.
Publicado: (2007)

Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v5nbtccig2nbvi8iofd3omqqns