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Mitochondrial genomic integrity and the nuclear epigenome in health and disease

Bidirectional crosstalk between the nuclear and mitochondrial genomes is essential for proper cell functioning. Mitochondrial DNA copy number (mtDNA-CN) and heteroplasmy influence mitochondrial function, which can influence the nuclear genome and contribute to health and disease. Evidence shows that...

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Detalles Bibliográficos
Autores principales: Morin, Amanda L., Win, Phyo W., Lin, Angela Z., Castellani, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678080/
https://www.ncbi.nlm.nih.gov/pubmed/36419771
http://dx.doi.org/10.3389/fendo.2022.1059085