Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear. We report a selective differentiation impairment in CR...

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Detalles Bibliográficos
Autores principales: Ostojić, Jelena, Yoon, Young-Sil, Sonntag, Tim, Nguyen, Billy, Vaughan, Joan M., Shokhirev, Maxim, Montminy, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678241/
https://www.ncbi.nlm.nih.gov/pubmed/34010639
http://dx.doi.org/10.1016/j.celrep.2021.109136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678241/
https://www.ncbi.nlm.nih.gov/pubmed/34010639
http://dx.doi.org/10.1016/j.celrep.2021.109136

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