Cargando…

Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear. We report a selective differentiation impairment in CR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ostojić, Jelena, Yoon, Young-Sil, Sonntag, Tim, Nguyen, Billy, Vaughan, Joan M., Shokhirev, Maxim, Montminy, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678241/ https://www.ncbi.nlm.nih.gov/pubmed/34010639 http://dx.doi.org/10.1016/j.celrep.2021.109136

Ejemplares similares

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members
por: Sonntag, Tim, et al.
Publicado: (2017)

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
por: Sonntag, Tim, et al.
Publicado: (2018)

Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes
por: Bertolotto, Corine, et al.
Publicado: (1998)

cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria
por: Peng, Li-qun, et al.
Publicado: (2016)

Rhynchosia volubilis Promotes Cell Survival via cAMP-PKA/ERK-CREB Pathway
por: Ahn, Sang-Hyun, et al.
Publicado: (2022)

Discovery of Pinostrobin as a Melanogenic Agent in cAMP/PKA and p38 MAPK Signaling Pathway
por: Yoon, Jeong-Hyun, et al.
Publicado: (2022)

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway
por: Hida, Tokimasa, et al.
Publicado: (2009)

Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis
por: Zhang, Eric E., et al.
Publicado: (2010)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
por: Oldenburger, Anouk, et al.
Publicado: (2012)

Integration of Global Signaling Pathways, cAMP-PKA, MAPK and TOR in the Regulation of FLO11
por: Vinod, P. K., et al.
Publicado: (2008)

cAMP crosses junctions
por: Bashyam, Hema
Publicado: (2007)

Mitochondrial cAMP signaling
por: Zhang, Fan, et al.
Publicado: (2016)

Anti-Thrombotic Effects of Artesunate through Regulation of cAMP and PI3K/MAPK Pathway on Human Platelets
por: Yoon, Shin-Sook, et al.
Publicado: (2022)

Endosomal cAMP production broadly impacts the cellular phosphoproteome
por: Tsvetanova, Nikoleta G., et al.
Publicado: (2021)

Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics
por: Ruso-Julve, Fulgencio, et al.
Publicado: (2019)

The A(2B) Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells
por: Giacomelli, Chiara, et al.
Publicado: (2018)

Cyclic 3', 5'-AMP relay in dictyostelium discoideum. IV. Recovery of the cAMP signaling response after adaptation to cAMP
por: Dinauer, M, et al.
Publicado: (1980)

Cyclic 3', 5'-AMP relay dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation
por: Dinauer, M, et al.
Publicado: (1980)

Suppression of Virulence of Toxigenic Vibrio cholerae by Anethole through the Cyclic AMP (cAMP)-cAMP Receptor Protein Signaling System
por: Zahid, M. Shamim Hasan, et al.
Publicado: (2015)

Imaging cAMP nanodomains in the heart
por: Chao, Ying-Chi, et al.
Publicado: (2019)

TNFα-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes
por: Takeuchi, Rika, et al.
Publicado: (2019)

Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes
por: Ikoma-Seki, Keiko, et al.
Publicado: (2015)

cAMP is an allosteric modulator of DNA-binding specificity in the cAMP receptor protein from Mycobacterium tuberculosis
por: Gárate, Fernanda, et al.
Publicado: (2021)

An Improved Genetically Encoded Fluorescent cAMP Indicator for Sensitive cAMP Imaging and Fast Drug Screening
por: Liu, Wenfeng, et al.
Publicado: (2022)

The Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells
por: Maymó, Julieta Lorena, et al.
Publicado: (2012)

Cyclic 3',5'-AMP relay in Dictyostelium discoideum III. The relationship of cAMP synthesis and secretion during the cAMP signaling response
Publicado: (1980)

Direct regulation of the natural competence regulator gene tfoX by cyclic AMP (cAMP) and cAMP receptor protein (CRP) in Vibrios
por: Wu, Rui, et al.
Publicado: (2015)

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes
por: Chae, Jae Kyoung, et al.
Publicado: (2017)

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes
por: Richards, Mark, et al.
Publicado: (2016)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling
por: Koschinski, Andreas, et al.
Publicado: (2017)

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei
por: Bachmaier, Sabine, et al.
Publicado: (2023)

Development of green fluorescent protein-based cAMP indicators for covering a wide range of cAMP concentrations
por: Hiasa, Sohei, et al.
Publicado: (2023)

Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways
por: Baek, Seung‐hwa, et al.
Publicado: (2015)

Carvedilol, an Adrenergic Blocker, Suppresses Melanin Synthesis by Inhibiting the cAMP/CREB Signaling Pathway in Human Melanocytes and Ex Vivo Human Skin Culture
por: Choi, Myoung Eun, et al.
Publicado: (2020)

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation
por: Gündüz, Dursun, et al.
Publicado: (2019)

p-Hydroxylcinnamaldehyde induces the differentiation of oesophageal carcinoma cells via the cAMP-RhoA-MAPK signalling pathway
por: Ma, Ming, et al.
Publicado: (2016)

Beauvericin inhibits melanogenesis by regulating cAMP/PKA/CREB and LXR-α/p38 MAPK–mediated pathways
por: Lee, Seung Eun, et al.
Publicado: (2018)

Revisiting cAMP signaling in the carotid body
por: Nunes, Ana R., et al.
Publicado: (2014)

Mechanisms Restricting Diffusion of Intracellular cAMP
por: Agarwal, Shailesh R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_92dpgh53hph1ci18s1us8qnhj2