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Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear. We report a selective differentiation impairment in CR...

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Detalles Bibliográficos
Autores principales:	Ostojić, Jelena, Yoon, Young-Sil, Sonntag, Tim, Nguyen, Billy, Vaughan, Joan M., Shokhirev, Maxim, Montminy, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678241/ https://www.ncbi.nlm.nih.gov/pubmed/34010639 http://dx.doi.org/10.1016/j.celrep.2021.109136

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