ATRX modulates the escape from a telomere crisis

Telomerase activity is the principal telomere maintenance mechanism in human cancers, however 15% of cancers utilise a recombination-based mechanism referred to as alternative lengthening of telomeres (ALT) that leads to long and heterogenous telomere length distributions. Loss-of-function mutations...

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Detalles Bibliográficos
Autores principales: Geiller, Helene E. B., Harvey, Adam, Jones, Rhiannon E., Grimstead, Julia W., Cleal, Kez, Hendrickson, Eric A., Baird, Duncan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678338/
https://www.ncbi.nlm.nih.gov/pubmed/36350851
http://dx.doi.org/10.1371/journal.pgen.1010485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678338/
https://www.ncbi.nlm.nih.gov/pubmed/36350851
http://dx.doi.org/10.1371/journal.pgen.1010485

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