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A systematic review of the biological mediators of fat taste and smell

Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential target...

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Autores principales: Jaime-Lara, Rosario B., Brooks, Brianna E., Vizioli, Carlotta, Chiles, Mari, Nawal, Nafisa, Ortiz-Figueroa, Rodrigo S. E., Livinski, Alicia A., Agarwal, Khushbu, Colina-Prisco, Claudia, Iannarino, Natalia, Hilmi, Aliya, Tejeda, Hugo A., Joseph, Paule V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678415/
https://www.ncbi.nlm.nih.gov/pubmed/36409650
http://dx.doi.org/10.1152/physrev.00061.2021
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author Jaime-Lara, Rosario B.
Brooks, Brianna E.
Vizioli, Carlotta
Chiles, Mari
Nawal, Nafisa
Ortiz-Figueroa, Rodrigo S. E.
Livinski, Alicia A.
Agarwal, Khushbu
Colina-Prisco, Claudia
Iannarino, Natalia
Hilmi, Aliya
Tejeda, Hugo A.
Joseph, Paule V.
author_facet Jaime-Lara, Rosario B.
Brooks, Brianna E.
Vizioli, Carlotta
Chiles, Mari
Nawal, Nafisa
Ortiz-Figueroa, Rodrigo S. E.
Livinski, Alicia A.
Agarwal, Khushbu
Colina-Prisco, Claudia
Iannarino, Natalia
Hilmi, Aliya
Tejeda, Hugo A.
Joseph, Paule V.
author_sort Jaime-Lara, Rosario B.
collection PubMed
description Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity.
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spelling pubmed-96784152022-11-30 A systematic review of the biological mediators of fat taste and smell Jaime-Lara, Rosario B. Brooks, Brianna E. Vizioli, Carlotta Chiles, Mari Nawal, Nafisa Ortiz-Figueroa, Rodrigo S. E. Livinski, Alicia A. Agarwal, Khushbu Colina-Prisco, Claudia Iannarino, Natalia Hilmi, Aliya Tejeda, Hugo A. Joseph, Paule V. Physiol Rev Review Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity. American Physiological Society 2023-01-01 2022-09-15 /pmc/articles/PMC9678415/ /pubmed/36409650 http://dx.doi.org/10.1152/physrev.00061.2021 Text en Copyright © 2023 The Authors https://creativecommons.org/licenses/by/4.0/Licensed under Creative Commons Attribution CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/) . Published by the American Physiological Society.
spellingShingle Review
Jaime-Lara, Rosario B.
Brooks, Brianna E.
Vizioli, Carlotta
Chiles, Mari
Nawal, Nafisa
Ortiz-Figueroa, Rodrigo S. E.
Livinski, Alicia A.
Agarwal, Khushbu
Colina-Prisco, Claudia
Iannarino, Natalia
Hilmi, Aliya
Tejeda, Hugo A.
Joseph, Paule V.
A systematic review of the biological mediators of fat taste and smell
title A systematic review of the biological mediators of fat taste and smell
title_full A systematic review of the biological mediators of fat taste and smell
title_fullStr A systematic review of the biological mediators of fat taste and smell
title_full_unstemmed A systematic review of the biological mediators of fat taste and smell
title_short A systematic review of the biological mediators of fat taste and smell
title_sort systematic review of the biological mediators of fat taste and smell
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678415/
https://www.ncbi.nlm.nih.gov/pubmed/36409650
http://dx.doi.org/10.1152/physrev.00061.2021
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