Survivin promotes a glycolytic switch in CD4(+) T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of IFNγ-producing T cells acting through the transcriptional control of glucose utilization. High expression of survivin in CD4(+)T cells was associated with IFNγ-dependent phenotype and anaerobic glycolysis...

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Detalles Bibliográficos
Autores principales: Erlandsson, Malin C., Andersson, Karin M.E., Oparina, Nina Y., Chandrasekaran, Venkataragavan, Saghy, Tibor, Damdimopoulos, Anastasios, Garcia-Bonete, Maria-Jose, Einbeigi, Zakaria, Silfverswärd, Sofia T., Pekna, Marcela, Katona, Gergely, Bokarewa, Maria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678772/
https://www.ncbi.nlm.nih.gov/pubmed/36425763
http://dx.doi.org/10.1016/j.isci.2022.105526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678772/
https://www.ncbi.nlm.nih.gov/pubmed/36425763
http://dx.doi.org/10.1016/j.isci.2022.105526

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