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Novel variants provide differential stabilisation of human equilibrative nucleoside transporter 1 states

Human equilibrative nucleoside transporters represent a major pharmaceutical target for cardiac, cancer and viral therapies. Understanding the molecular basis for transport is crucial for the development of improved therapeutics through structure-based drug design. ENTs have been proposed to utilise...

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Detalles Bibliográficos
Autores principales: Boakes, Jessica C., Harborne, Steven. P. D., Ngo, Jessie T. S., Pliotas, Christos, Goldman, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678926/
https://www.ncbi.nlm.nih.gov/pubmed/36425655
http://dx.doi.org/10.3389/fmolb.2022.970391