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Ca(2+) binding to synapsin I regulates resting Ca(2+) and recovery from synaptic depression in nerve terminals
Synapsin I (SynI) is a synaptic vesicle (SV)-associated phosphoprotein that modulates neurotransmission by controlling SV trafficking. The SynI C-domain contains a highly conserved ATP binding site mediating SynI oligomerization and SV clustering and an adjacent main Ca(2+) binding site, whose physi...
Autores principales: | Moschetta, Matteo, Ravasenga, Tiziana, De Fusco, Antonio, Maragliano, Luca, Aprile, Davide, Orlando, Marta, Sacchetti, Silvio, Casagrande, Silvia, Lignani, Gabriele, Fassio, Anna, Baldelli, Pietro, Benfenati, Fabio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678998/ https://www.ncbi.nlm.nih.gov/pubmed/36409372 http://dx.doi.org/10.1007/s00018-022-04631-5 |
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