Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients

BACKGROUND: Apart from bactericidal effects, anti-tuberculosis drugs can interfere with the host’s immune system. In this study, we analyzed the role of delamanid (DLM), an inhibitor of mycolic acid synthesis of mycobacterial cell wall, on human macrophages. METHODS: Based on a cohort of multidrug-r...

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Detalles Bibliográficos
Autores principales: Qiao, Min, Li, Shanshan, Yuan, Jinfeng, Ren, Weicong, Shang, Yuanyuan, Wang, Wei, Liu, Rongmei, Zhang, Fuzhen, Li, Qing, Wu, Xiao, Lu, Jie, Gao, Mengqiu, Pang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679411/
https://www.ncbi.nlm.nih.gov/pubmed/36426362
http://dx.doi.org/10.3389/fimmu.2022.923492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679411/
https://www.ncbi.nlm.nih.gov/pubmed/36426362
http://dx.doi.org/10.3389/fimmu.2022.923492

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