Cargando…

The βI domain promotes active β1 integrin clustering into mature adhesion sites

Modulation of integrin function is required in many physiological and pathological settings, such as angiogenesis and cancer. Integrin allosteric changes, clustering, and trafficking cooperate to regulate cell adhesion and motility on extracellular matrix proteins via mechanisms that are partly defi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mana, Giulia, Valdembri, Donatella, Askari, Janet A, Li, Zhenhai, Caswell, Patrick, Zhu, Cheng, Humphries, Martin J, Ballestrem, Christoph, Serini, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679427/ https://www.ncbi.nlm.nih.gov/pubmed/36410791 http://dx.doi.org/10.26508/lsa.202201388

Ejemplares similares

Conformationally active integrin endocytosis and traffic: why, where, when and how?
por: Mana, Giulia, et al.
Publicado: (2020)

The roles of integrins in cancer
por: Valdembri, Donatella, et al.
Publicado: (2021)

TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism
por: Ariano, Camilla, et al.
Publicado: (2022)

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells
por: Valdembri, Donatella, et al.
Publicado: (2009)

Focal adhesions are sites of integrin extension
por: Askari, Janet A., et al.
Publicado: (2010)

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
por: Mana, Giulia, et al.
Publicado: (2016)

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling
por: Sandri, Chiara, et al.
Publicado: (2012)

Marching at the front and dragging behind: differential αVβ3-integrin turnover regulates focal adhesion behavior
por: Ballestrem, Christoph, et al.
Publicado: (2001)

Class 3 semaphorins in cardiovascular development
por: Valdembri, Donatella, et al.
Publicado: (2016)

Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interaction
por: Baade, Timo, et al.
Publicado: (2019)

Mechanosensitive components of integrin adhesions: Role of vinculin
por: Atherton, Paul, et al.
Publicado: (2016)

LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion
por: Camillo, Chiara, et al.
Publicado: (2021)

The primacy of affinity over clustering in regulation of adhesiveness of the integrin α(L)β(2)
por: Kim, Minsoo, et al.
Publicado: (2004)

Integrin-specific signaling pathways controlling focal adhesion formation and cell migration
por: Mostafavi-Pour, Zohreh, et al.
Publicado: (2003)

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment
por: Byron, Adam, et al.
Publicado: (2012)

Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program
por: Regano, Donatella, et al.
Publicado: (2017)

Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins
por: Battistini, Chiara, et al.
Publicado: (2019)

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation
por: Xu, Huifang, et al.
Publicado: (2012)

The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering
por: Ellis, Stephanie J., et al.
Publicado: (2014)

β1 integrin is a sensor of blood flow direction
por: Xanthis, Ioannis, et al.
Publicado: (2019)

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION
por: Mould, A. Paul, et al.
Publicado: (2016)

Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
por: Cascone, Ilaria, et al.
Publicado: (2005)

IL-1β mediated nanoscale surface clustering of integrin α5β1 regulates the adhesion of mesenchymal stem cells
por: Maynard, Stephanie A., et al.
Publicado: (2021)

αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
por: Worth, Daniel C., et al.
Publicado: (2010)

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
por: Horton, Edward R., et al.
Publicado: (2016)

The integrin adhesome network at a glance
por: Horton, Edward R., et al.
Publicado: (2016)

Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing
por: Belkin, Alexey M., et al.
Publicado: (1997)

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly
por: Horton, Edward R., et al.
Publicado: (2015)

Growth Factor–dependent Activation of αvβ3 Integrin in Normal Epithelial Cells: Implications for Tumor Invasion
por: Trusolino, Livio, et al.
Publicado: (1998)

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin α(IIb)β(3)
por: Hato, Takaaki, et al.
Publicado: (1998)

Direct evidence for cell adhesion-mediated radioresistance (CAM-RR) on the level of individual integrin β1 clusters
por: Babel, Laura, et al.
Publicado: (2017)

Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling
por: Morgan, Mark R., et al.
Publicado: (2013)

Vinculin controls focal adhesion formation by direct interactions with talin and actin
por: Humphries, Jonathan D., et al.
Publicado: (2007)

Talin activates integrins by altering the topology of the β transmembrane domain
por: Kim, Chungho, et al.
Publicado: (2012)

p190RhoGAP is the convergence point of adhesion signals from α(5)β(1) integrin and syndecan-4
por: Bass, Mark D., et al.
Publicado: (2008)

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
por: Beaty, Brian T., et al.
Publicado: (2013)

Modulation of β1A Integrin Functions by Tyrosine Residues in the β1 Cytoplasmic Domain
por: Sakai, Takao, et al.
Publicado: (1998)

Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function
por: Lu, Zhenwei, et al.
Publicado: (2016)

Aβ oligomers promote oligodendrocyte differentiation and maturation via integrin β1 and Fyn kinase signaling
por: Quintela-López, Tania, et al.
Publicado: (2019)

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1
por: Serini, Guido, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_m7dho2schrpc2ejki5nt9oe3do