Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-making

Tumor mutation burden (TMB) has been validated as a biomarker to predict the response of immune checkpoint inhibitors (ICIs) treatment in various cancers. However, the effects of different sequencing platforms, cancer types, and calculation algorithms on TMB as well as its cut-off value for predicti...

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Detalles Bibliográficos
Autores principales: Sun, Daqiang, Xu, Meilin, Pan, Chaohu, Tang, Hongzhen, Wang, Peng, Wu, Dongfang, Luo, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679647/
https://www.ncbi.nlm.nih.gov/pubmed/36425562
http://dx.doi.org/10.3389/fonc.2022.972972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679647/
https://www.ncbi.nlm.nih.gov/pubmed/36425562
http://dx.doi.org/10.3389/fonc.2022.972972

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