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Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-making
Tumor mutation burden (TMB) has been validated as a biomarker to predict the response of immune checkpoint inhibitors (ICIs) treatment in various cancers. However, the effects of different sequencing platforms, cancer types, and calculation algorithms on TMB as well as its cut-off value for predicti...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679647/ https://www.ncbi.nlm.nih.gov/pubmed/36425562 http://dx.doi.org/10.3389/fonc.2022.972972 |