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EGFR exon 20 insertion variants A763_Y764insFQEA and D770delinsGY confer favorable sensitivity to currently approved EGFR-specific tyrosine kinase inhibitors

Background: The EGFR exon 20 insertions (ex20ins) D770_N771insSVD and V769_D770insASV are most frequent in non-small-cell lung cancer (NSCLC) and are associated with intrinsic resistance to currently approved EGFR tyrosine kinase inhibitors (TKIs). A763_Y764insFQEA and D770delinsGY, respectively, ac...

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Detalles Bibliográficos
Autores principales: Yang, Guangjian, Yang, Yaning, Hu, Jiaqi, Xu, Haiyan, Zhang, Shuyang, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679652/
https://www.ncbi.nlm.nih.gov/pubmed/36425568
http://dx.doi.org/10.3389/fphar.2022.984503