Mass photometry reveals SARS-CoV-2 spike stabilisation to impede ACE2 binding through altered conformational dynamics

Here we show using mass photometry how proline substitutions, commonly used for SARS-CoV-2 spike stabilisation in vaccine design, directly affects ACE2 receptor interactions via dynamics of open and closed states. Conformational changes and ACE2 binding were influenced by spike variant and temperatu...

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Detalles Bibliográficos
Autores principales: Burnap, Sean A., Struwe, Weston B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680610/
https://www.ncbi.nlm.nih.gov/pubmed/36317551
http://dx.doi.org/10.1039/d2cc04711j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680610/
https://www.ncbi.nlm.nih.gov/pubmed/36317551
http://dx.doi.org/10.1039/d2cc04711j

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