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Deciphering the conformational dynamics of gephyrin-mediated collybistin activation

Efficient neuronal signaling depends on the proper assembly of the postsynaptic neurotransmitter machinery. The majority of inhibitory synapses feature γ-aminobutyric acid type A (GABA(A)) receptors. The function of these GABAergic synapses is controlled by the scaffolding protein gephyrin and colly...

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Detalles Bibliográficos
Autores principales: Imam, Nasir, Choudhury, Susobhan, Hemmen, Katherina, Heinze, Katrin G., Schindelin, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680708/
https://www.ncbi.nlm.nih.gov/pubmed/36425671
http://dx.doi.org/10.1016/j.bpr.2022.100079