Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity

Antitumour inflammatory cytokines are highly toxic when systemically administered. Here, in multiple syngeneic mouse models, we show that the intratumoural injection of recombinantly expressed cytokines bound tightly to the common vaccine adjuvant aluminium hydroxide (alum) (via ligand exchange betw...

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Detalles Bibliográficos
Autores principales: Agarwal, Yash, Milling, Lauren E., Chang, Jason Y.H., Santollani, Luciano, Sheen, Allison, Lutz, Emi A., Tabet, Anthony, Stinson, Jordan, Ni, Kaiyuan, Rodrigues, Kristen A., Moyer, Tyson J., Melo, Mariane B., Irvine, Darrell J., Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681025/
https://www.ncbi.nlm.nih.gov/pubmed/35013574
http://dx.doi.org/10.1038/s41551-021-00831-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681025/
https://www.ncbi.nlm.nih.gov/pubmed/35013574
http://dx.doi.org/10.1038/s41551-021-00831-9

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