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Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity
Antitumour inflammatory cytokines are highly toxic when systemically administered. Here, in multiple syngeneic mouse models, we show that the intratumoural injection of recombinantly expressed cytokines bound tightly to the common vaccine adjuvant aluminium hydroxide (alum) (via ligand exchange betw...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681025/ https://www.ncbi.nlm.nih.gov/pubmed/35013574 http://dx.doi.org/10.1038/s41551-021-00831-9 |