Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis

CD8 + cytotoxic T cell responses against viral infection represent a major element of the adaptive immune response. We describe the development of a peptide antigen – major histompatibility complex (pMHC) library representing the full SARS-CoV-2 viral proteome, and comprised of 634 pMHC multimers re...

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Detalles Bibliográficos
Autores principales: Heath, James, Chour, William, Choi, Jongchan, Xie, Jingyi, Chaffee, Mary, Schmitt, Thomas, Finton, Kathryn, Delucia, Diana, Xu, Alexander, Su, Yapeng, Chen, Daniel, Zhang, Rongyu, Yuan, dan, Hong, Sunga, Ng, Alphonsus, Butler, Jonah, Edmark, Rick, Jones, Lesley, Murray, Kim, Peng, Songming, Li, Guideng, Strong, Roland, Lee, John, Goldman, Jason, Greenberg, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681053/
https://www.ncbi.nlm.nih.gov/pubmed/36415462
http://dx.doi.org/10.21203/rs.3.rs-1090664/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681053/
https://www.ncbi.nlm.nih.gov/pubmed/36415462
http://dx.doi.org/10.21203/rs.3.rs-1090664/v1

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