Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy

The long-sought-after “magic bullet” in systemic therapy remains unrealized for disease targets existing inside most tissues, theoretically because vascular endothelium impedes passive tissue entry and full target engagement. We engineered the first “dual precision” bispecific antibody with one arm...

Descripción completa

Detalles Bibliográficos
Autores principales: Kadam, Anil H., Kandasamy, Kathirvel, Buss, Tim, Cederstrom, Brittany, Yang, Chun, Narayanapillai, Sreekanth, Rodriguez, Juan, Levin, Michael D., Koziol, Jim, Olenyuk, Bogdan, Borok, Zea, Chrastina, Adrian, Schnitzer, Jan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681080/
https://www.ncbi.nlm.nih.gov/pubmed/36413536
http://dx.doi.org/10.1371/journal.pone.0276462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681080/
https://www.ncbi.nlm.nih.gov/pubmed/36413536
http://dx.doi.org/10.1371/journal.pone.0276462

Ejemplares similares