Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

Non-structural protein 1 (Nsp1) is a main pathogenicity factor of α- and β-coronaviruses. Nsp1 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suppresses the host gene expression by sterically blocking 40S host ribosomal subunits and promoting host mRNA degradation. This mechanism le...

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Detalles Bibliográficos
Autores principales: Borsatto, Alberto, Akkad, Obaeda, Galdadas, Ioannis, Ma, Shumeng, Damfo, Shymaa, Haider, Shozeb, Kozielski, Frank, Estarellas, Carolina, Gervasio, Francesco Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681203/
https://www.ncbi.nlm.nih.gov/pubmed/36412088
http://dx.doi.org/10.7554/eLife.81167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681203/
https://www.ncbi.nlm.nih.gov/pubmed/36412088
http://dx.doi.org/10.7554/eLife.81167

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