R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton

Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly associated with bone density. Here, we investigated the role of Rspo3 in skeletal homeostasis in mice. Using a compreh...

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Detalles Bibliográficos
Autores principales: Nagano, Kenichi, Yamana, Kei, Saito, Hiroaki, Kiviranta, Riku, Pedroni, Ana Clara, Raval, Dhairya, Niehrs, Christof, Gori, Francesca, Baron, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681208/
https://www.ncbi.nlm.nih.gov/pubmed/36321691
http://dx.doi.org/10.7554/eLife.84171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681208/
https://www.ncbi.nlm.nih.gov/pubmed/36321691
http://dx.doi.org/10.7554/eLife.84171

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