Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identificat...

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Detalles Bibliográficos
Autores principales: Boot, James, Rosser, Gabriel, Kancheva, Dailya, Vinel, Claire, Lim, Yau Mun, Pomella, Nicola, Zhang, Xinyu, Guglielmi, Loredana, Sheer, Denise, Barnes, Michael, Brandner, Sebastian, Nelander, Sven, Movahedi, Kiavash, Marino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681209/
https://www.ncbi.nlm.nih.gov/pubmed/36412091
http://dx.doi.org/10.7554/eLife.77335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681209/
https://www.ncbi.nlm.nih.gov/pubmed/36412091
http://dx.doi.org/10.7554/eLife.77335

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