Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identificat...

Descripción completa

Detalles Bibliográficos
Autores principales: Boot, James, Rosser, Gabriel, Kancheva, Dailya, Vinel, Claire, Lim, Yau Mun, Pomella, Nicola, Zhang, Xinyu, Guglielmi, Loredana, Sheer, Denise, Barnes, Michael, Brandner, Sebastian, Nelander, Sven, Movahedi, Kiavash, Marino, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681209/
https://www.ncbi.nlm.nih.gov/pubmed/36412091
http://dx.doi.org/10.7554/eLife.77335

Ejemplares similares

Ejemplares similares