Spread of pathological human Tau from neurons to oligodendrocytes and loss of high-firing pyramidal neurons in aging mice

Intracellular aggregation of hyperphosphorylated Tau (pTau) in the brain is associated with cognitive and motor impairments, and ultimately neurodegeneration. We investigate how human pTau affects cells and network activity in the hippocampal formation of the THY-Tau22 tauopathy model mice in vivo....

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Detalles Bibliográficos
Autores principales: Viney, Tim J., Sarkany, Barbara, Ozdemir, A. Tugrul, Hartwich, Katja, Schweimer, Judith, Bannerman, David, Somogyi, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681663/
https://www.ncbi.nlm.nih.gov/pubmed/36384116
http://dx.doi.org/10.1016/j.celrep.2022.111646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681663/
https://www.ncbi.nlm.nih.gov/pubmed/36384116
http://dx.doi.org/10.1016/j.celrep.2022.111646

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