Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS

Loss of SFPQ is a hallmark of motor degeneration in ALS and prevents maturation of motor neurons when occurring during embryogenesis. Here, we show that in zebrafish, developing motor neurons lacking SFPQ exhibit axon extension, branching and synaptogenesis defects, prior to degeneration. Subcellula...

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Detalles Bibliográficos
Autores principales: Taylor, Richard, Hamid, Fursham, Fielding, Triona, Gordon, Patricia M., Maloney, Megan, Makeyev, Eugene V., Houart, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681851/
https://www.ncbi.nlm.nih.gov/pubmed/36414621
http://dx.doi.org/10.1038/s41467-022-34331-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681851/
https://www.ncbi.nlm.nih.gov/pubmed/36414621
http://dx.doi.org/10.1038/s41467-022-34331-4

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