Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11

Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show that polyglutamylation, a still understudied post-translational modification of spindle MTs, is essential to define their dynamics within the range required for error-free ch...

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Detalles Bibliográficos
Autores principales: Zadra, Ivan, Jimenez-Delgado, Senda, Anglada-Girotto, Miquel, Segura-Morales, Carolina, Compton, Zachary J., Janke, Carsten, Serrano, Luis, Ruprecht, Verena, Vernos, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681853/
https://www.ncbi.nlm.nih.gov/pubmed/36414642
http://dx.doi.org/10.1038/s41467-022-34909-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681853/
https://www.ncbi.nlm.nih.gov/pubmed/36414642
http://dx.doi.org/10.1038/s41467-022-34909-y

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