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The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester
This study demonstrates that intravenous infusion of the cell-penetrant thiol ester, L-cysteine ethyl ester (L-CYSee), to adult male Sprague-Dawley rats elicited (a) minor alterations in frequency of breathing, expiratory time, tidal volume, minute ventilation, or expiratory drive but pronounced cha...
Autores principales: | Lewis, Tristan H.J., May, Walter J., Young, Alex P., Bates, James N., Baby, Santhosh M., Getsy, Paulina M., Ryan, Rita M., Hsieh, Yee-Hsee, Seckler, James M., Lewis, Stephen J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682160/ https://www.ncbi.nlm.nih.gov/pubmed/36411626 http://dx.doi.org/10.1016/j.biopha.2022.113939 |
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