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Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants

Herpes simplex virus (HSV) infection is a leading cause of corneal blindness. However, keratoplasty is only rarely proposed due to the high frequency of graft failure and associated recurrences. Gene therapy of the corneal graft might provide sustained protection against HSV infection. To test that...

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Detalles Bibliográficos
Autores principales: Chapellier, Benoit, Guindolet, Damien, Pereira, Daniel, Galetto, Roman, Sahel, José-Alain, Labetoulle, Marc, Gabison, Eric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682361/
https://www.ncbi.nlm.nih.gov/pubmed/36457698
http://dx.doi.org/10.1016/j.omtn.2022.11.006